Aspergillus and Aspergillosis podcasts
By Aspergillus Website
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Podcast Description
Sufferers of the wide range of health problems caused by the fungus aspergillus come from several different health groups; ABPA, CPA, asthmatics, CGD, CF and more. We present here a series of talks aimed at those patients and given by world experts in each field
| Name | Description | Released | Price | ||
|---|---|---|---|---|---|
| 1 | VideoAspergillus and CGD by Brahm Segal | Chronic granulomatous disorder (CGD) is the result of a genetic mutation and causes excessive inflammation. Invasive mould infection is the most significant cause of mortality in CGD, and Aspergillus is the most common cause of pneumonia for people with this condition, so the need to destroy the Aspergillus but minimise inflammation calls for treatment with a combination of antifungal agents and steroids. However, there are often few signs that people are infected. | 5 5 10 | Free | View In iTunes |
| 2 | VideoSteroids, Aspergillus and antifungals. | Steroids are used to control inflammation in ABPA, but giving people cortisone suppresses their own production of cortisol (important for coping with stress and providing a feedback mechanism for the immune system) and can produce side effects including muscle weakness, diabetes mellitus, cardiovascular complications, glaucoma, depression and osteoporosis. Steroids affect natural immunity, suppressing cell-mediated immunity and masking the symptoms of infection. The risk of negative effects of steroid use can be minimised by direct administration of the medication to the lungs, and by using the minimum necessary dose. Many drugs need to be modified by the liver before excretion. Azole antifungals (e.g. Itraconazole, Voriconazole and Posaconazole) work by inhibiting an enzyme found in fungi, but can also inhibit liver function. | 5 5 10 | Free | View In iTunes |
| 3 | VideoWhy is invasive aspergillosis such a difficult disease to diagnose and treat? by Marta Stanzani | Mortality in invasive aspergillosis depends largely on the timing of the intervention, timely diagnosis and the state of the patient’s defences, treatment is much more effective when people have an intact immune system. Effective intervention depends on knowledge of the condition, high awareness of the possibility of its occurrence, early recognition and early treatment. Early diagnosis requires continuous and specific screening. | 4 5 10 | Free | View In iTunes |
| 4 | VideoHow can I clean up my environment at home? by Malcolm Richardson | There is evidence that occupants of damp or mouldy buildings are at increased risk of respiratory symptoms, that remediation of dampness can reduce adverse health outcomes, that exposure to mould increases the risk of various conditions and that allergic people are particularly susceptible. | 27 4 10 | Free | View In iTunes |
| 5 | VideoHow important is Aspergillus in cystic fibrosis? by Rick Moss | CF often has some of the features of allergic bronchopulmonary aspergillosis (ABPA), and ABPA may be diagnosed in people with CF when there is evidence of clinical deterioration, a high IgE level, an allergic reaction to Aspergillus on skin or blood testing, presence of IgG antibodies and new abnormalities on chest X-ray. As ABPA hastens the loss of lung function in CF, there is an argument for screening for ABPA in people with CF from school age, and treating the condition with corticosteroids and antifungals. | 21 4 10 | Free | View In iTunes |
| 6 | VideoChronic Pulmonary Aspergillosis by David Denning | The prognosis is good for people with CPA once treatment has been established, although there is evidence that long-term treatment is necessary to prevent relapse. As there is an increasing problem with azole resistance, the use of azoles needs to be well monitored. | 21 4 10 | Free | View In iTunes |
| 7 | VideoGetting antifungal levels right - why does it matter? by David Andes | Antifungal drugs (e.g. Itraconazole, Voricaonazole and Posaconazole) have a variable and unpredictable dose–concentration relationship, and therefore need careful concentration management. Problems may occur whether the concentration is either too low or too high, and it is difficult to maintain a concentration that falls within the therapeutic window. | 20 4 10 | Free | View In iTunes |
| 8 | VideoSurgery for aspergilloma and invasive aspergillosis by Gilbert Massard (43.29min) | Surgical resection should be considered for only the most dangerous of lesions. Factors predicting a low rate of operative complication are youth, lack of underlying lung disease and limited resection; operative death rate for this procedure is about 10%. | 20 4 10 | Free | View In iTunes |
| Total: 8 Episodes |
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