In an elegant Spanish-style apartment complex in the trendy Melrose neighborhood of Los Angeles, the lives and relationships of a diverse group of 20-somethings intertwine to form a close-knit surrogate family. Sydney Andrews is the landlady, still beautiful at 40, and a central figure in the lives of all her tenants, especially handsome and rebellious David Breck. Another tenant, high-powered publicist Ella Simms, once considered Sydney her mentor, but their friendship was destroyed by betrayal.
The other tenants include Lauren Yung, a medical student in desperate need of money to pay her student loans, and Jonah Miller, an aspiring filmmaker who has just proposed to his live-in girlfriend Riley Richmond, a first-grade teacher. The newest tenant, wide-eyed 21-year-old Violet Foster, has just arrived in LA and is horrified to find a bloody body floating in the courtyard pool. David is the leading suspect but, as the police are soon to discover, almost everyone living at Melrose Place had a reason to want the deceased out of the way.