Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)
Pure and Applied Chemistry 2008, August, 80, 8
Pure and Applied Chemistry
This book is available for download with iBooks on your Mac or iOS device, and with iTunes on your computer. Books can be read with iBooks on your Mac or iOS device.
Abstract: A series of cyclic ADP-ribose (cADPR) analogs, in which modifications mainly focused on riboses, was synthesized in order to explore the molecular mechanism of calcium release regulated by cADPR. Biological activities investigated in intact T-lymphocytes showed that the structurally simplified analogs, N1-ethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPRE), N1,N9-diethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPDE), and N1-ethoxymethyl-substituted cyclic adenosine diphosphoribose (cADPRE) in which the northern ribose or both northern and southern riboses were replaced by ether linkages are membrane-permeant and induce calcium release from intracellular stores. This research has provided novel molecules to probe cADPR-mediated calcium signaling and enlarges our knowledge of the structure-activity relationships of cADPR analogs. Keywords: cADPR analogs; agonists; nucleotides; synthesis; signal messengers.
- 2,99 €
- Category: Chemistry
- Published: 01 August 2008
- Publisher: International Union of Pure and Applied Chemistry
- Print Length: 9 Pages
- Language: English