Use of Functionalized [Beta]-Lactams As Building Blocks in Heterocyclic Chemistry (Report)
Pure and Applied Chemistry 2010, Sept, 82, 9
Pure and Applied Chemistry
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INTRODUCTION The class of [beta]-lactam antibiotics is generally recognized as a cornerstone of human health care due to the unparalleled clinical efficacy and safety of this type of antibacterials . For example, the world antibiotics market is dominated by Augmentin, a combination of amoxicillin 1 and potassium clavulanate 2, produced by GlaxoSmithKline. Nevertheless, the recent appearance of highly resistant bacteria profoundly challenges the way medicinal chemists contemplate innovation of the [beta]-lactam structure and corroborates the need for continuous efforts within this field of research.
- 2,99 €
- Category: Chemistry
- Published: 01 September 2010
- Publisher: International Union of Pure and Applied Chemistry
- Print Length: 17 Pages
- Language: English