HIV Treatment Interruptions: A Review (Data Review)
Research Initiative/Treatment Action! 2003, Fall, 9, 2
Research Initiative/Treatment Action!
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INTRODUCTION The widespread use of highly active antiretroviral therapy (HAART) has bad a significant impact on HIV by reducing mortality and morbidity. (1) Unfortunately, long-term use of antiretroviral treatment is associated with several limitations and drawbacks. Currently available antiretrovirals are unable to completely eradicate the HIV infection, and infectious virus continues to reside and to replicate latently in reservoirs. As a result, most patients will be on antiretroviral therapy for the rest of' their lives, a situation that could potentially cause severe side effects and drug toxicity. These include, but are certainly not limited to, high triglyceride and cholesterol levels, insulin resistance, diabetes, and redistribution of body fat--many of which increase the likelihood of suffering a cardiac event. Adherence is difficult because of the daily, long-term drug dosing requirements and incidence of side effects, and there is a continuous risk of an emergence of drug-resistant HIV. (2,3) Finally, because of the extremely high cost of antiretroviral treatment, 95% of HIV-infected individuals worldwide do not have access to HAART. (4)
- 2,99 €
- Category: Health & Fitness
- Published: 22 September 2003
- Publisher: The Center for AIDS: Hope & Remembrance Project
- Print Length: 20 Pages
- Language: English