Desmopressin (Ddavp) Incident Signals the Need for Enhanced Monitoring Protocols (ISMP Canada) (Case Study)
Dynamics 2008, Fall, 19, 3
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Background In central (also called cranial) diabetes insipidus, secretion of antidiuretic hormone (ADH) from the pituitary gland is absent (or insufficient) (Singer & Sevilla, 2003). This leads to a water metabolism disorder characterized by hypotonic polyuria (very high urine output with reduced osmolality (i.e., reduced proportion of solutes to fluid) due to the inability of the kidneys to conserve free water in the absence (or lack) of ADH. This disproportionate loss in electrolyte-free water can lead to hypernatremia, resulting in increased serum osmolality and the movement of free water from cells, which can lead to intracellular dehydration. Patients will exhibit prominent and constant symptoms of thirst if they are alert and have a normal thirst mechanism (Singer & Sevilla, 2003). The central diabetes insipidus may be transient, occurring after neurosurgery or other trauma on or near the pituitary gland, or it may be chronic.
- Category: Industries & Professions
- Published: Sep 22, 2008
- Publisher: Canadian Association of Critical Care Nurses
- Seller: The Gale Group, Inc.
- Print Length: 8 Pages
- Language: English