Nature Podcast Springer Nature Limited

Growing up in Alabama in the 1960s, mathematician Freeman Hrabowski was moved to join the civil rights moment after hearing Martin Luther King Jr speak. Even as a child, he saw the desperate need to make change. He would go on to do just that — at the University of Maryland Baltimore County, where he co-founded the Meyerhoff Scholars Program, one of the leading pathways to success for Black students in STEM subjects in the United States.
Freeman is the subject of the first in a new series of Q&As in Nature celebrating ‘Changemakers’ in science — individuals who fight racism and champion inclusion. He spoke to us about his about his life, work and legacy.
Career Q&A: I had my white colleagues walk in a Black student’s shoes for a day

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AIs are often described as 'black boxes' with researchers unable to to figure out how they 'think'. To better understand these often inscrutable systems, some scientists are borrowing from psychology and neuroscience to design tools to reverse-engineer them, which they hope will lead to the design of safer, more efficient AIs.
This is an audio version of our Feature: How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models

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00:45 The neuroscience of fentanyl addictionResearch in mice has shown that fentanyl addiction is the result of two brain circuits working in tandem, rather than a single neural pathway as had been previously thought. One circuit underlies the positive feelings this powerful drug elicits, which the other was responsible for the intense withdrawal when it is taken away. Opioid addiction leads to tens of thousands of deaths each year, and the team hopes that this work will help in the development of drugs that are less addictive.
Research Article: Chaudun et al.

09:16 Research HighlightsHow an ‘assembloid’ could transform how scientists study drug delivery to the brain, and an edible gel that prevents and treats alcohol intoxication in mice.
Research Highlight: Organoids merge to model the blood–brain barrier
Research Highlight: How cheesemaking could cook up an antidote for alcohol excess
11:36: Briefing ChatWhy babies are taking the South Korean government to court, and Europe’s efforts to send a nuclear-powered heater to Mars.
Nature News: Why babies in South Korea are suing the government
Nature News: Mars rover mission will use pioneering nuclear power source
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In this episode:
00:45 A recyclable 3D printing resin from an unusual sourceMany 3D printers create objects using liquid resins that turn into robust solids when exposed to light. But many of these are derived from petrochemicals that are difficult to recycle. To overcome this a team has developed a new type of resin, which they’ve made using a bodybuilding supplement called lipoic acid. Their resin can be printed, recycled and reused multiple times, which they hope could in future contribute to reducing waste associated with 3D printing.
Research Article: Machado et al
10:05 Research HighlightsHow housing shortages can drive a tiny parrot resort to kill, and the genes that gave cauliflower its curls.
Research Highlight: These parrots go on killing sprees over real-estate shortages
Research Highlight: How the cauliflower got its curlicues
12:27 To learn how to make safe structures researchers... destroyed a buildingMany buildings are designed to prevent collapse by redistributing weight following an initial failure. However this relies on extensive structural connectedness that can result in an entire building being pulled down. To prevent this, researchers took a new approach inspired by the ability of some lizards to shed their tails. They used this to develop a modular system, which they tested by building — and destroying — a two storey structure. Their method stopped an initial failure from spreading, preventing a total collapse. The team hope this finding will help prevent catastrophic collapses, reducing loss of life in aid rescue efforts.
Research Article: Makoond et al.
Nature video: Controlled failure: The building designed to limit catastrophe
23:20: Briefing ChatAn AI algorithm discovers 27,500 new asteroids, and an exquisitely-accurate map of a human brain section reveals cells with previously undiscovered features.
New York Times: Killer Asteroid Hunters Spot 27,500 Overlooked Space Rocks
Nature News: Cubic millimetre of brain mapped in spectacular detail
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Subscribe to Nature Briefing: AI and robotics

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In this episode:
00:45 A nuclear timekeeper that could transform fundamental-physics research.Nuclear clocks — based on tiny shifts in energy in an atomic nucleus — could be even more accurate and stable than other advanced timekeeping systems, but have been difficult to make. Now, a team of researchers have made a breakthrough in the development of these clocks, identifying the correct frequency of laser light required to make this energy transition happen. Ultimately it’s hoped that physicists could use nuclear clocks to probe the fundamental forces that hold atoms together.
News: Laser breakthrough paves the way for ultra precise ‘nuclear clock’
10:34 Research HighlightsWhy life on other planets may come in purple, brown or orange, and a magnetic fluid that could change shape inside the body.
Research Highlight: Never mind little green men: life on other planets might be purple
Research Highlight: A magnetic liquid makes for an injectable sensor in living tissue
13:48 AlphaFold gets an upgradeDeepmind’s AlphaFold has revolutionised research by making it simple to predict the 3D structures of proteins, but it has lacked the ability to predict situations where a protein is bound to another molecule. Now, the AI has been upgraded to AlphaFold 3 and can accurately predict protein-molecule complexes containing DNA, RNA and more. Whilst the new version is restricted to non-commercial use, researchers are excited by its greater range of predictive abilities and the prospect of speedier drug discovery.
News: Major AlphaFold upgrade offers huge boost for drug discovery
Research Article: Abramson et al.
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Ever since scientific enquiry began, people have focused mainly on men, or if studies involve animals, on male mice, male rats or whatever it may be. And this has led to gaps in scientists’ understanding of how diseases, and responses to treatment, and many other things might vary between people of different sexes and genders.
These days, mainly thanks to big funders like the NIH introducing new guidelines and mandates, a lot more scientists are thinking about sex and, where appropriate, gender. And this has led to a whole host of discoveries.
But all this research is going on within a sociopolitical climate that’s becoming increasingly hostile and polarized, particularly in relation to gender identity. And in some cases, science is being weaponized to push agendas, creating confusion and fear.
It is clear that sex and gender exist beyond a simple binary. This is widely accepted by scientists and it is not something we will be debating in this podcast. But this whole area is full of complexity, and there are many discussions which need to be had around funding, inclusivity or research practices.
To try to lessen fear, and encourage clearer, less divisive thinking, we have asked three contributors to a special series of opinion pieces on sex and gender to come together and thrash out how exactly scientists can fill in years of neglected research – and move forward with exploring the differences between individuals in a way that is responsible, inclusive and beneficial to as many people as possible.
Read the full collection: Sex and gender in science

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