After Dean gives up hunting, Sam is mysteriously freed from his cage in hell and finds Dean to tell him he must rejoin the fight.
Sam investigates when the parents of missing babies are murdered; Dean reluctantly leaves Ben and Lisa to help Sam.
Sam and Dean seek Castiel's help when they investigate a case of police officers who seem to have been killed by Egyptian plagues.
Bobby asks Dean and Sam for help after Crowley refuses to return Bobby's soul; a deep secret about Crowley is revealed.
After young girls go missing, Dean and Sam realize vampires have come to town; Dean is bitten during a fight with two vampires.
Sam and Dean investigate a rash of suicides and discover that someone is invoking the Goddess of Truth to drive the victims crazy.
Jared Padalecki
Sam Winchester
Jensen Ackles
Dean Winchester
Misha Collins
Castiel
Alexander Calvert
Jack
Mark Sheppard
Crowley