Season Five of the internationally acclaimed series finds Detective William Murdoch in the Yukon trying his luck as the Klondike Gold Rush winds down. In the wake of his personal and professional problems, Murdoch has left Toronto intent on starting a new life. But despite his suspension and Dr. Ogden's recent marriage to another man, Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.
Upon his return to the detective beat, Murdoch finds that Dr. Ogden has taken on an accomplished female protégé, Dr. Emily Grace (Georgina Reilly,) a feisty and adept young coroner who immediately catches Constable Crabtree's eye. Murdoch will be surprised further by Dr. Ogden's actions when the awkwardness between them becomes palpable.
Among the complex investigations this season, Murdoch must tread carefully after a Protestant politician is assassinated, most likely by Catholic adversaries. He'll also find himself in the company of aspiring novelist Jack London (Aaron Ashmore,) emerging industrialist Henry Ford and even anarchists when he infiltrates a group led by labour leader Emma Goldman. Inspector Brackenreid gets swept up in his own personal drama while he and Murdoch investigate the attempted murder of an international opera diva (Measha Brueggergosman.) And the debut of Crabtree's adventure novel, The Curse of the Lost Pharaohs, coincides with an Egyptian antiquities exhibition that appears to be threatened by a vengeful mummy's curse.
Later in the season, Dr. Ogden takes the lead on pushing medical practices into the next century by teaching contraception to young women, despite the legal consequences. Murdoch's personal life is reinvigorated when he discovers his former love Anna Fulford (Lisa Faulkner) working in Toronto under an alias, but the threat of the Black Hand crime syndicate continues to linger over their relationship. The season ends with the turn of the 20th century, and questions about the future following a case of supposed time traveling - will Brackenreid accept a new role in Ottawa and leave the department? Will Crabtree and Dr. Grace's professional relationship become a personal one? And what, and more importantly whom, does Murdoch's future hold?