Abriendo iTunes Store.Si iTunes no se abre, haz clic en el icono de la aplicación iTunes en el Dock de Mac o en el escritorio de Windows.Progress Indicator
Abriendo el iBooks Store.Si iBooks no se abre, haz clic en la app iBooks del Dock.Progress Indicator

iTunes is the world's easiest way to organize and add to your digital media collection.

No encontramos iTunes en este ordenador. Para obtener descargas del iTunes Store, obtén iTunes ahora.

¿Ya tienes iTunes? Haz clic en Tengo iTunes para abrirlo ahora.

I Have iTunes Descarga gratuita
iTunes para Mac + PC

Promoting Safe and Effective Genetic Tests in the United States: Work of the Task Force on Genetic Testing (Clinical Chemistry Forum)

Clinical Chemistry 1999, May, 45, 5

Este libro está disponible para descargarlo con iBooks en tu Mac o dispositivo iOS, y con iTunes en tu ordenador. Puedes usar iBooks para leer libros en tu Mac o dispositivo iOS.


Since I spoke at this Forum in 1993 (1), the emphasis in human genetics research has shifted from rare Mendelian disorders to common, complex diseases, but "Issues of benefits and risks of genetic testing", the title of my earlier presentation, have, if anything, become more important. The growing interest of clinical researchers in the role of genes in common diseases and of commercial firms in genetic testing lends new urgency to establishing benefits and risks. Large collaborative projects have been undertaken to look for gene loci at which the presence of specific alleles increase the risk of asthma, bipolar affective disorder, diabetes, hypertension, schizophrenia, and other disorders. The last 5 years have seen the marketing of commercial tests for predicting risks of breast and colon cancer despite warnings of the Advisory Council of the National Human Genome Research Institute and, separately, the American Society of Human Genetics that testing for susceptibility to common cancers should be conducted on a research basis only (2, 3). A commercially available test for the apolipoprotein E e4 allele was available to predict the risk of Alzheimer disease until professional statements criticized its use in clinically unaffected individuals (4,5). It remains on the market for diagnostic testing. A survey completed for the Task Force on Genetic Testing early in 1995 found that 53 biotechnology companies were developing or performing tests for genetic disorders. The companies were much more likely to be developing tests for common complex disorders than for relatively rare single gene disorders (Table 1) (6). Reflecting concern about the rapid proliferation of genetic tests before their safety and effectiveness had been demonstrated, the NIH-Department of Energy (NIH-DOE) (1) Working Group on Ethical, Legal, and Social Implications of Human Genome Research (ELSI) convened the Task Force on Genetic Testing in 1995. The ELSI Working Group asked the Task Force to review genetic testing in the United States and, when necessary, to make recommendations to ensure the development of safe and effective genetic tests. Part of the review was accomplished by the survey already mentioned. The Task Force defined safety and effectiveness "to encompass not only the validity and utility of genetic tests, but their delivery in laboratories of assured quality, and their appropriate use by healthcare providers and consumers" [Ref. (7), p. 4]. I will discuss these components, and the recommendations of the Task Force for ensuring safety and effectiveness of newly developed genetic tests.

Promoting Safe and Effective Genetic Tests in the United States: Work of the Task Force on Genetic Testing (Clinical Chemistry Forum)
Ver en iTunes
  • 2,99 €
  • Disponible en iPhone, iPad, iPod touch y Mac.
  • Categoría: Química
  • Publicación: 01/05/1999
  • Editorial: American Association for Clinical Chemistry, Inc.
  • Páginas impresas: 25 páginas
  • Idioma: Inglés
  • Requisitos: Para ver este libro, debes tener un dispositivo iOS con iBooks 1.3.1 (o posterior) y iOS 4.3.3 (o posterior), o un Mac con iBooks 1.0 (o posterior) y OS X 10.9 (o posterior).

Valoraciones de clientes

No hemos recibido suficientes valoraciones para poder mostrar un promedio de este artículo.