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It's late in the 21st century and bioengineering is now so common that people are able to modify their minds in any way they wish. It is an era which has been shaped by information systems so vast that security, in any form, is easily breached. Now you can be whatever you want to be, and do whatever you want to do. On Earth anyway.
One night, thirty three years ago, the stars went out. 'The Bubble' - a perfect sphere centred on the sun - appeared in the sky, isolating the solar system from the rest of the universe. For thirty-three years, humanity has lived with the religious cults and terrorism which spawned in the wake of the darkness.
We are now alone. Humanity has been cut off. Quarantined.