iTunes

Opening the iTunes Store.If iTunes doesn’t open, click the iTunes icon in your Dock or on your Windows desktop.Progress Indicator
Opening the iBooks Store.If iBooks doesn't open, click the iBooks app in your Dock.Progress Indicator
iTunes

iTunes is the world's easiest way to organize and add to your digital media collection.

We are unable to find iTunes on your computer. To download from the iTunes Store, get iTunes now.

Do you already have iTunes? Click I Have iTunes to open it now.

I Have iTunes Free Download
iTunes for Mac + PC

To T Or Not to T, That is the Question (Editorial)

Clinical Chemistry 1997, March, 43, 3

This book is available for download with iBooks on your Mac or iOS device, and with iTunes on your computer. Books can be read with iBooks on your Mac or iOS device.

Description

The quest for a test that is absolutely disease- and tissue-specific could be considered the Holy Grail of the clinical chemist, dreamt of but seldom achieved. Initial reports on measurement of the cardiac troponins, cardiac troponin T (cTnT) and cardiac troponin I (cTnI), for diagnosis of myocardial infarction suggested that these markers would become the "gold standard," replacing all other existing tests. Questions have been raised as to the specificity of cTnT for cardiac damage in patients with extreme rhabdomyolysis, renal failure, polymyositis, and muscular dystrophy. This problem is addressed by the papers of Bodor et al. [1] and Muller-Bardorff et al. [2] in this issue of Clinical Chemistry. This is therefore a reasonable time to review what we know at the basic science level and how this relates to both papers and current clinical practice. Cardiac and skeletal muscle cells are closely related but arise from different embryonic lineages and express distinctive gene sets when terminally differentiated. During embryonic development, both muscle types cross-express several genes. There are three troponin T genes, corresponding to slow skeletal, fast skeletal, and cardiac troponin. During early embryonic development, the cTnT gene is activated and transcribed at relatively low levels in both cardiac and skeletal muscles until mid-fetal development, when expression is divergently regulated. In cardiac cells, transcription of the cTnT gene is sharply up-regulated, whereas in the skeletal cells it is repressed [3-5]. Similarly, three isoforms of troponin I exist, also the products of three separate genes: fast skeletal muscle, slow skeletal muscle, and cardiac muscle troponin I. During fetal development, slow skeletal muscle troponin I is the predominant isoform in the heart. After birth, the slow skeletal isoform is lost such that, by 9 months of postnatal development, the cardiac isoform is the only detectable isoform [6,7].

To T Or Not to T, That is the Question (Editorial)
View in iTunes
  • £2.99
  • Available on iPhone, iPad, iPod touch, and Mac.
  • Category: Chemistry
  • Published: 01 March 1997
  • Publisher: American Association for Clinical Chemistry, Inc.
  • Print Length: 13 Pages
  • Language: English
  • Requirements: To view this book, you must have an iOS device with iBooks 1.3.1 or later and iOS 4.3.3 or later, or a Mac with iBooks 1.0 or later and OS X 10.9 or later.

Customer Ratings

We have not received enough ratings to display an average for this book.