Michigan Academician 2008, Wntr, 38, 4
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Mycobacterium chlorophenolicum and Its Ability to Survive in the Presence of Pentachlorophenol. Rachael Glassford, and Darin McCarthy, Calvin College, Department of Chemistry and Biochemistry, Grand Rapids, MI 49546 Pentachlophenol (PCP), a wood preservative banned in 1987 due to its toxicity, continues to contaminate sites around the world and presents an environmental cleanup challenge. M. chlorophenolicum has been isolated from PCP-contaminated sites and has the ability to survive in the presence of PCP, despite the fact that this toxin interferes with oxidative phosphorylation. Out goal is to understand the mechanisms by which M. chlorophenolicum both survives in the presence of, and degrades PCP Although PCP induces a lag phase in M. chlorophenolicum growth, PCP-treated cells grow at the same rate as control cultures. However, PCP inhibits growth in control mycobacteria, M. smegmatis and M. phlei. In addition, cellular respiration in M. chlorophenolicum is significantly inhibited at high concentrations of PCP, but is uncoupled in control strains. The effect of PCP on respiration is pH dependent; oxygen consumption is inhibited more strongly at low pH. These results indicate that M. chlorophenolicum is uniquely able to survive in the presence of PCP because it enters a dormant state at high PCP concentrations, thus not wasting energy that would be lost due to uncoupling of oxidative phosphorylation.
- 2,99 €
- Category: Reference
- Published: 01 January 2008
- Publisher: Michigan Academy of Science Arts & Letters
- Print Length: 12 Pages
- Language: English