Food Addiction and Obesity: Evidence from Bench to Bedside (Report)
Journal of Psychoactive Drugs, 2010, June, 42, 2
Journal of Psychoactive Drugs
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It is well known that overeating is the leading cause of obesity, though the overall etiology is not well explained (Merlo & Gold 2009). Overeating is considered as an addiction that comes from a variety of psychological as well as physiological causes (Gold et al. 2009). In particular, binge eating has been categorized as an eating disorder in the proposed revision of DSM IV. Another factor is the effect of emotions associated with the reward system of the brain (Joranby, Pineda & Gold 2005). There are numerous theories that are beyond the scope of this review as to why food addiction occurs, such as deviant eating processes involving homeostasis and hedonic effects (Lutter & Nestler 2009; Becker et al. 2004). It is well recognized that the hypothalamus is the key component for maintaining homeostasis in the body, and is responsive to signals that regulate food intake. Thus, if these signals are aberrant in any way, this could lead to delayed feelings of satiety in the individual (Liu et al. 2000). The intrinsic and extrinsic signaling pathways (Sahu & Kalra 1993) describe which neuropeptides regulate food intake. Aside from the physiological explanations, food intake is regulated by the hedonic or reward-based system that can override the homeostatic signal when there is relatively abundant energy by increasing the desire to consume foods that are highly palatable (Lutter & Nestler 2009; Joranby, Pineda & Gold 2005).
- Category: Health & Fitness
- Published: 01 June 2010
- Publisher: Taylor & Francis Ltd.
- Print Length: 47 Pages
- Language: English