Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, And Diabetes on Risk of Coronary Heart Disease in Chinese (Lipids, Lipoproteins, And Cardiovascular Risk Factors) Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, And Diabetes on Risk of Coronary Heart Disease in Chinese (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, And Diabetes on Risk of Coronary Heart Disease in Chinese (Lipids, Lipoproteins, And Cardiovascular Risk Factors‪)‬

Clinical Chemistry 2008, June, 54, 6

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Publisher Description

Coronary heart disease (CHD) [5] is a multifactorial disease, and autoimmunity is considered to be one of its most important mechanisms (1). Heat shock protein (Hsp) is a possible autoantigenic determinant that mayplayasignificantroleinthedevelopmentofatherosclerosis. High concentrations of antibody to human Hsp60 (anti-Hsp60) have been shown to be associated with CHD in small case-control studies (276 cases/129 controls and 424 cases/321 controls, respectively) (2, 3). In a cross-sectional study, a strong association was detected between concentrations of anti-Hsp60 and both the presence and the severity of CHD in 391 patients (4). However, no association between IgG anti-Hsp60 and levels of coronary calcification was found in201 healthy, asymptomatic subjects (5). Huittinen et al. (6) found no association between coronary risk and IgG anti-Hsp60 in dyslipidemic middle-aged males (239 case-control pairs). Kocsis et al. (7) reported that anti-Hsp60 concentration did not predict the development of new cardiovascular events. These inconsistent results may be due to differences in study populations and small sample sizes. A recent study (8) indicated that there may be ethnic differences in the circulating concentrations of Hsps. Our previous studies (9) found a significant association between anti-Hsp60 and increased risk of electrocardiographic abnormalities characteristic of chronic myocardial ischemia, sinus arrhythmia, and ectopic rhythm. Therefore, we further tested whether there was a dose-response relationship between anti-Hsp60 and the risk of CHD in a Chinese Han population. In addition, we examined joint effects of anti-Hsp60, hypertension, and diabetes on risk of CHD because previous studies have suggested that anti-Hsp60 may also be involved in hypertension (10) and diabetes (11-13). Materials and Methods

GENRE
Science & Nature
RELEASED
2008
1 June
LANGUAGE
EN
English
LENGTH
18
Pages
PUBLISHER
American Association for Clinical Chemistry, Inc.
SIZE
228.8
KB

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