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V(D)J Recombination

Pierre Ferrier

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Description

V(D)J Recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many—from experienced scientists to trainees—it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simply considered as a private ground for a few aficionados, it can be seen as a way of understanding how mature lymphocytes carry on their basic functions. For the group of aficionados—which includes this editor—it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likely hijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig and TCR) loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNA repair machinery as well as various DNA polymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity.

V(D)J Recombination
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  • 149,99 €
  • Available on iPhone, iPad, iPod touch, and Mac.
  • Category: Medical
  • Published: 24 December 2009
  • Publisher: Springer New York
  • Print Length: 211 Pages
  • Language: English
  • Requirements: To view this book, you must have an iOS device with iBooks 1.3.1 or later and iOS 4.3.3 or later, or a Mac with iBooks 1.0 or later and OS X 10.9 or later.

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