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Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)

Pure and Applied Chemistry 2008, August, 80, 8

Pure and Applied Chemistry

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Description

Abstract: A series of cyclic ADP-ribose (cADPR) analogs, in which modifications mainly focused on riboses, was synthesized in order to explore the molecular mechanism of calcium release regulated by cADPR. Biological activities investigated in intact T-lymphocytes showed that the structurally simplified analogs, N1-ethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPRE), N1,N9-diethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPDE), and N1-ethoxymethyl-substituted cyclic adenosine diphosphoribose (cADPRE) in which the northern ribose or both northern and southern riboses were replaced by ether linkages are membrane-permeant and induce calcium release from intracellular stores. This research has provided novel molecules to probe cADPR-mediated calcium signaling and enlarges our knowledge of the structure-activity relationships of cADPR analogs. Keywords: cADPR analogs; agonists; nucleotides; synthesis; signal messengers.

Adenine-Based Calcium Signal Pathway Messengers: Synthesis and Agonistic Properties of Cyclic Adp-Ribose Analogs (Adenosine Diphosphate) (Report)
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  • 2,99 €
  • Available on iPhone, iPad, iPod touch, and Mac.
  • Category: Chemistry
  • Published: 01 August 2008
  • Publisher: International Union of Pure and Applied Chemistry
  • Print Length: 9 Pages
  • Language: English
  • Requirements: To view this book, you must have an iOS device with iBooks 1.3.1 or later and iOS 4.3.3 or later, or a Mac with iBooks 1.0 or later and OS X 10.9 or later.

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