- Saddle River Stringband
- Salmon Philippe
- Sam Carr's Delta Jukes
- Sam Collins
- Sam Lightnin' Hopkins & Thunder Smith
- Sam O.G
- Sam Phillips
- Sam Roark
- Sammusic
- Samuel James
- Sandor Enyedi
- Sandro Dunn
- Sanguine
- Sanu Dharan
- Sarah Frank
- Sasha Gracanin
- Satyavel .S
- Savoy Brown
- Sboshwa
- Schorsch Hampel
- Scott H. Biram
- Sea Gypsy 101
- Seasick Steve
- Seth Di Marco
- Seth James
- Shaddy
- Shania Tw
- Shayne McCarter
- Sheila & The Caddo Kats
- Shelby Dirrim
- Sherazade Tamzought
- Sherif Guirguis
- Shubha Mudgal
- Sideways 8 Country
- Sign1st
- Simmonds
- Simple 3
- Sister Rosetta Tharpe
- Skip James
- Sky Lambourne
- Slash LaRue
- Sleeping Orchard
- Sleepy John Estes
- Slide Boy Roy
- Slim Harpo
- Small King
- Smokey Wilson
- Smoky Babe
- Solex
- Son House
- Sonia Sox
- Sonny Boy Williamson
- Sonny Terry
- Sonny Terry & Brownie McGhee
- Sonny Terry with Brownie McGhee & J.C. Burris
- Sophia Avocado
- Sonny Terry with Brownie McGhee & J.C. Burris
- Sophia Avocado
- Soroush Marandi
- South Memphis String Band
- Southern Comfort
- Spank Me Tender
- Spirit
- Spooky Tooth
- Srinik Chinu
- Stan Jankaitis
- Stan Webb
- Star Styles
- Starlight
- Steamhammer
- Stefan Grossman
- Steve Cropper
- Steve Earle
- Steve Fawcett
- Steve Mayhew
- Steve Ripley
- Steve Winwood
- Steven K. and the Bounty Hunters
- Strainful Train
- Stringbean & the Stalkers
- Summer Ashly
- Suraj Mehra
- Suvindu Atapattu