Mutagenic Activity of Idarubicin and Epirubicin in the Bacterium Salmonella Typhimurium.
The Texas Journal of Science 2002, August, 54, 3
The Texas Journal of Science
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Abstract. -- Idarubicin (structural analogue of daunomycin) and epirubicin (epimer of adriamycin) are two "second-generation" anthracyclines that are widely used in chemotherapy against leukemias and metastatic breast tumors, respectively. This study shows that using the Salmonella Mutagenicity Assay that idarubicin, like daunomycin, can induce frameshift (TA98; 16.1 fold), GC to AT (TA7004; 8.7 fold), and AT to GC base-substitution transition mutations (TA7001; 2.8 fold). Epirubicin, like adriamycin, can also induce frameshift (19.7 fold) and GC to AT transition mutations (14.6 fold) in this assay. Interestingly, epirubicin, but not adriamycin, can induce AT to GC mutations (2.9 fold) in this assay. **********
- 2,99 €
- Category: Engineering
- Published: 01 August 2002
- Publisher: Texas Academy of Science
- Print Length: 18 Pages
- Language: English