- S. E. P. P. - Special Ensemble Peter & Piefke
- Sadiki Fuller
- Sam Jay
- Sam Kinison
- Sam Moss
- Sam Tonning
- Sam Tripoli
- Sameer Suri
- Sammy Obeid
- Sandra Bernhard
- Sara Schaefer
- Sarah Perry
- Sarah Silverman
- Schmitti
- Schwarze Grütze
- Scott Gibson
- Sean Kent
- Sean McDonnell
- Sean Rouse
- Sebastian Maniscalco
- Sebastian Rejent
- Selena Coppock
- Shalewa Sharpe
- Shang
- Shawn Pelofsky
- Shayma Tash
- Shecky Greene
- Shelley Berman
- Sheng Wang
- Sibbeschuss
- Sid Singh
- Sid Singh
- Sidetrackedcast
- Sierra Katow
- Silva Gonzalez
- Simeon Goodson
- Simon Carmiggelt
- Simon Gibson
- Simon King
- Sinbad
- Sir Erwin
- Slappy White
- Slavcho Peykov
- Smothers Brothers
- Sol Bernstein
- Sommore
- Son of a Beach
- Sonny and Pepper
- Spanky Brown
- Spencer James
- Spike Jones
- Spitzbua Markus
- Stacey Jones
- Stand-up Polska
- Steev Letts
- Stefan Raab
- Steffen Kersken & Friends
- Steph Tolev
- Stephen K Amos
- Stephen Thomas
- Stermann & Grissemann
- Steve AKA Mudflap McGrew
- Steve Byrne
- Steve Gillespie
- Steve Harvey
- Steve Hofstetter
- Steve Hughes
- Steve Martin
- Steve McGrew
- Steve Mudflap McGrew
- Steve Simeone
- Steve Trevino
- Steve White
- Steve Wilson
- Steven Alan
- Steven Briggs
- Steven Pearl
- Steven Roberts
- Steven Wright
- Stewart Francis
- Stroy Moyd
- Stuart Jones
- Sulaiman Masomi
- Suli McCullough
- Super Renzullo
- Surinaamse Cabaret Musical
- Suzanne Westenhoefer
- Sydney Castillo
- Sydney Davis Jr Jr
- Sylvan Productions
- Sylvie Joly