The efforts of trumpeter and keyboardist Frank London extend to klezmer music, film music, avant-garde jazz, contemporary classical music, pop and rock, and more; he has performed with musicians ranging from vocalist Mel Tormé to avant-garde composer John Zorn. Much of his music has some connection with Jewish themes. London made his recording debut in 1980 on the album Film Noir by jazz pianist Ran Blake. He is a longtime member of the progressive klezmer band the Klezmatics and has founded two groups of his own, Frank London's Klezmer Brass All-Stars and Hasidic New Wave. London's recordings range from cantorial music and Jewish mystical songs to the folk opera A Night in the Old Marketplace. In 2023, London appeared on the multi-artist album Killdeer; by that time, he had appeared on well over 200 recordings.