Introduction to Biology
By Prof. Eric Lander Prof. Robert Weingberg Dr. Claudette Gardel
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The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.012 focuses on the exploration of current research in cell biology, immunology, neurobiology, genomics, and molecular medicine.
|1||VideoLecture 1: Introduction||Introduction to Biology; History of Earth; Prokaryotic and Eukaryotic Cells; Importance of Biology; Organelles of Various Cell Types; Organelles of the Eukaryotic Cell||7/10/2015||Free||View in iTunes|
|2||VideoLecture 2: Biochemistry 1||Atoms, Bonds, and Molecules in Biology; Hydrophobic, Hydrophilic, and Amphipathic Molecules; Interactions Between Biological Molecules; Phospholipid Bilayer; Carbohydrates Overview; Polymerization of Macromolecules||7/10/2015||Free||View in iTunes|
||Lecture 03: Biochemistry 2 (audio only)||This course covers the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. The focus of the course is on the exploration of current research in cell biology, immunology, neurobiology, genomics, and molecular medicine.||6/20/2007||Free||View in iTunes|
|4||VideoLecture 4: Biochemistry 3||Review of Protein Structure; Transmembrane Proteins; Post-translational Modification; Nucleic Acid Structure, Bases, Nomenclature, Polymerization; Nomenclature; Double Helix, Base Complementarity; DNA Replication, Transcription; RNA Double Helix||7/10/2015||Free||View in iTunes|
|5||VideoLecture 5: Biochemistry 4||Origin and Purpose of RNA; Biochemical Reactions, Energy, and Enzymes; Glycolysis and Krebs Cycle; Energy Production of Anaerobic and Aerobic Respiration; Mitochondria Function and Production of ATP||7/10/2015||Free||View in iTunes|
|6||VideoLecture 6: Genetics 1||Intro to Lander's life; Biochemistry, Genetics, and Molecular Biology; Mendel; Mendel's Experiments and Law of Segregation; Test Crosses as Proofs for Mendel's Model; Definitions in Genetics; Chromosomal Theory of Inheritance I; Mendel's 2nd Law||7/10/2015||Free||View in iTunes|
|7||VideoLecture 7: Genetics 2||Review; Chromosomal Theory of Inheritance II; Mendel's Law of Independent Assortment; Genetic Linkage; Genetic Distance and Recombination; Genetic Maps; Sex Linkage||7/10/2015||Free||View in iTunes|
|8||VideoLecture 8: Genetics 3||Introduction to the lecture; Yeast -- Model Organism; Yeast Metabolic Pathways and Mutants; Diploid and Haploid Yeast; Genetic Tests to Characterize Mutant; Test of Epistasis I||7/10/2015||Free||View in iTunes|
|9||VideoLecture 9: Human Genetics||Test of Epistasis II; Human Genetics and Pedigrees; Properties of X-linked and Autosomal Dominant Inheritance; Other Influences of Inheritance; Consanguinity and Recessive Inheritance||7/10/2015||Free||View in iTunes|
|10||VideoLecture 10: Molecular Biology 1||Review and Intro to Molecular Biology; Transforming Principle -- Griffith's Experiment; Structure of DNA; Genetic Material -- Avery's Experiment; The Double Helix -- Watson and Crick; Semi-Conservative Replication -- Meselson-Stahl Experiment||7/10/2015||Free||View in iTunes|
|11||VideoLecture 11: Molecular Biology 2||Review; DNA Replication -- Components and Direction; DNA Replication -- Leading and Lagging Strands and Enzymes; DNA Replication -- Fidelity; DNA Replication -- DNA Polymerase; Transcription; Translation I||7/10/2015||Free||View in iTunes|
|12||VideoLecture 12: Molecular Biology 3||Translation II; Variation on DNA Replication; Replication and Transcription in Viruses; Post-Transcriptional Modifications; Alternative Splicing; Variations on Translation||7/10/2015||Free||View in iTunes|
|13||VideoLecture 13: Gene Regulation||Review; Gene Regulation -- Levels; Gene Regulation in Bacteria; Structure of the Lac Operon and Transcriptional Repressor; Experimental Evidence for the Lac Operon; Transcriptional Activator||7/10/2015||Free||View in iTunes|
|14||VideoLecture 14: Protein Localization||Protein Localization Overview; Protein Translocation Experiments; Translocation Pathway/Mechanism; Mitochondrial Translocation; Nuclear Translocation; Review||7/10/2015||Free||View in iTunes|
|15||VideoLecture 15: Recombinant DNA 1||Introduction to Molecular Biology; Cloning Genes -- Overview; Cloning -- Restriction Enzymes; Cloning -- DNA Ligases; Cloning -- Vectors/Plasmids; Cloning -- Transformation and Selection||7/10/2015||Free||View in iTunes|
|16||VideoLecture 16: Recombinant DNA 2||Cloning -- Review; Cloning by Complementation; Cloning by Sequence; Cloning by Position I||7/10/2015||Free||View in iTunes|
|17||VideoLecture 17: Recombinant DNA 3||Review; Cloning by Position II; Variations on Cloning; Expression Library; Restriction Mapping and Gel Electrophoresis; Sequencing DNA||7/10/2015||Free||View in iTunes|
|18||VideoLecture 18: Recombinant DNA 4||Red Sox; Sequencing Genome; Analyzing DNA Sequence; Polymerase Chain Reaction (PCR); PCR -- Application; Summary||7/10/2015||Free||View in iTunes|
|19||VideoLecture 19: Cell Cycle/Signaling||Intro; Cell Cycle -- Overview; Cell Growth and Division; Constant Mitosis; Cell Cycle -- Regulation I||7/10/2015||Free||View in iTunes|
|20||VideoLecture 20: Cancer||Cell Cycle -- Regulation II; Cancer Cells, Mutagens, and Carcinogens; Cancer and Mutations||7/10/2015||Free||View in iTunes|
|21||VideoLecture 21: Virology/Tumor Viruses||Mutagens and Carcinogens; Raus Sarcoma Virus and Cancer||7/10/2015||Free||View in iTunes|
|22||VideoLecture 22: Immunology 1||Viral Infections and Vaccines; Immune Response -- Mechanism; Antibody/Immunoglobulin Structure; Antibody Production; Immune Response -- Primary and Secondary||7/10/2015||Free||View in iTunes|
|23||VideoLecture 23: Immunology 2||Immunology -- Definitions and Clonal Expansion; Antibody Variability and VDJ Recombination; Implications of Antibody Variability; Antibody Classes; Humoral and Cellular Immunity; Macrophage and T Helper Cells I||7/10/2015||Free||View in iTunes|
|24||VideoLecture 24: AIDS||Macrophage and T Helper Cells II; T Cell-B Cell Interaction; AIDS and HIV||7/10/2015||Free||View in iTunes|
|25||VideoLecture 25: Genomics||Evolutionary Genomic Analysis||7/10/2015||Free||View in iTunes|
|26||VideoLecture 26: Nervous System 1||Neuron Structure; Neurobiology -- Introduction; Neurobiology -- Electrical Signals; Neurobiology -- Concentration Gradients and Membrane Proteins; Action Potential Mechanism; Propagating Action Potential||7/10/2015||Free||View in iTunes|
|27||VideoLecture 27: Nervous System 2||Experimental Patch Clamping; Synaptic Transmission; Post-Synaptic Cell/ Muscle-Nerve Synapse; Drugs and Neurotoxins; Nerve-Nerve Synapse; Neural Circuitry||7/10/2015||Free||View in iTunes|
|28||VideoLecture 28: Nervous System 3||Nervous System||7/10/2015||Free||View in iTunes|
|29||VideoLecture 29: Stem Cells/Cloning 1||Growth and Differentiation; Stem Cells -- Hematopoiesis; Stem Cells -- Self Renewal; More Stem Cells||7/10/2015||Free||View in iTunes|
|30||VideoLecture 30: Stem Cells/Cloning 2||Today we're going to talk a bit about todipotential stem cells, which are able to disperse descendants into all the different differentiation lineages in the body.||7/10/2015||Free||View in iTunes|
|31||VideoLecture 31: Molecular Medicine 1||The modern treatment of cancer, and how our understanding of the molecular biology of the disease really helps in developing radically new kinds of therapies.||7/10/2015||Free||View in iTunes|
|32||VideoLecture 32: Molecular Evolution||Molecular Evolution; Darwinian Model; Genetic Evidence for Evolution and Evolutionary Trees; Mitochondrial DNA and Y Chromosome; Polymorphisms; Genetics of Small Populations; Human Migration and the Out-of-Africa Theory; Cohen Y Chromosome||7/10/2015||Free||View in iTunes|
|33||VideoLecture 33: Molecular Medicine 2||Understanding molecular biology, biochemistry, genetics, to help us treat disease. Today my goal is to talk about this with respect to heart disease.||7/10/2015||Free||View in iTunes|
|34||VideoLecture 34: Human Polymorphisms and Cancer Classification||Genomics and where things are going.||7/10/2015||Free||View in iTunes|
|35||VideoLecture 35: Future of Biology||I'm going to spend today trying to broadcast into the future, forecast into the future I should say, about where all of what we've talked about this semester is taking us.||7/10/2015||Free||View in iTunes|
great review and update
I have watched the first 12 lecture and really liking this course! I took some organic chemistry and one course in genetics in 1972. Because of this I can follow the course and learn a lot. There is a problem with the first lectures because you cannot see the slides he is projecting and discussing. It is still possible to follow the gist. The genetics lectures are very clear and wonderful. I only wish I could listen to the audio on my ipod nano, but it will not play without the video.
Love this course!
Very clear and concise teachers and very easy to follow. As stated before, some of the projector slides aren't visible, but still easy enough to understand the concept.
Genetics instructor is good; biochemistry instructor not so much.
There are two instructors for this lecture series. The first instructor who introduces the material and covers biochemistry is hard to follow without supplementary materials. He does not do a good job of explaining the concepts, and doesn't seem to understand how to educate effectively. The instructor who tackles genetics, however, is very competent. His use of narratives as well as his repetition of core concepts makes him much easier to follow.
I prefer to listen to the UC Berkley lectures on the basic biology concepts, especially because the course follows the Neil A. Campbell textbook of Biology--a book I believe is easy to follow and very useful.
Since the MIT and UC Berkley lectures are both free for download, I would recommend using both to get a robust understanding of these concepts.