Frank (Bill Murray "Ocean's Eleven", "Charlie's Angels"), whose body is the "City of Frank" and host to its' inhabitants, falls victim a viral infection. It's up to white blood cell cop Osmosis Jones (Emmy Award winner Chris Rock "Down to Earth", "Lethal Weapon 4"), who patrols the city, to fight against the biological clock and stop the invading virus with the help of a cold tablet named Drix (Emmy Award winner David Hyde Pierce "Chain of Fools", TV's "Frasier"). Directed by the Farrelly brothers ("Me, Myself and Irene", "There's Something About Mary"). Also starring Molly Shannon ("Superstar", "Analyze This") and the voices of Academy Award nominee Laurence Fishburne ("The Matrix", "Othello"), William Shatner ("Star Trek", "Miss Congeniality") and musicians Brandy (TV's "Moesha") and Kid Rock.

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Trailers

Trailer

Ratings and Reviews

4.4 out of 5
178 Ratings

178 Ratings

55% TOMATOMETER

Critics Consensus: The animated portion of Osmosis is zippy and fun, but the live-action portion is lethargic.

10+ COMMON SENSE

Mostly animated PG film has gross-out humor, violence.

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