After receiving a generous grant from the American Medical Association to find a cure for cancer, Dr. Duke Chawla (Bobby Deol), who always gives hope to his patients, proposes to his sweetheart, Pooja (Kangana Ranaut), and both arrange to get married soon. While returning home that night, he meets with an accident and wakes up in the East West Hospital paralyzed from the neck down with virtually no chance of recovery. Shattered and devastated, he is in for more trauma and shock when he finds out that Pooja will have nothing to do with him anymore. Upset, bitter and in despair, he loses his will to live, refuses to take either medicine or any treatment, and awaits death. One day, Roshan Suraj Sharma (Dwij Yadav) a young boy enters Duke's life to rekindle the candle of hope again.
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