Illumina Genomics Podcast
By Illumina, Inc.
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Hear directly from the people whose work in genomics is shaping the way we think about science and our world. Listen as leading scientists discuss the impact of genomics with the Illumina Scientific Affairs team. Download or subscribe to our recurring podcasts.
||CleanEpisode 34: Estonia ─ A Model for Precision Healthcare||Dr. Tõnu Esko is Deputy Director of Research at the Estonian Biobank of the University of Tartu. He joins me to talk about the Estonian Biobank and to explain how Estonia aims to create a national system to enable precision healthcare through genomic profiling.||1/9/2019||Free||View in iTunes|
||CleanEpisode 33: RNA Sequencing ─ a Cell Biology Tool||Dr. Joshua Weiner is Professor of Biology at the University of Iowa and Associate Director of the Iowa Neuroscience Institute. His lab uses a wide range of molecular and cell biology techniques to study the brain. Josh is a cell biologist by training, but he joins me to share his experiences on recently incorporating next-generation sequencing, or NGS, to complement his cell biology work.||12/18/2018||Free||View in iTunes|
||CleanEpisode 32: Genome Editing ─ CRISPR-Cas9 and Beyond||The CRISPR-Cas9 genome editing system is enabling scientists to make specific DNA changes in the genomes of plants and animals and has the potential to greatly impact our world. Dr. Sam Sternberg, Assistant Professor of Biochemistry and Molecular Biophysics at Columbia University, joins me to discuss the biology and impact of CRISPR and genome editing.||12/11/2018||Free||View in iTunes|
||CleanEpisode 31: Noninvasive Prenatal Testing ─ NIPT||In noninvasive prenatal testing (NIPT), a maternal blood sample provides maternal DNA as well as DNA from the pregnancy to screen prenatal chromosomal abnormalities using next-generation sequencing, or NGS. Dr. Ronald J. Wapner, Vice Chair of Research in Obstetrics and Gynecology for Columbia University, joins me to share his perspective on prenatal screening and NIPT.||11/1/2018||Free||View in iTunes|
||CleanEpisode 30: Genomics of Long-Term Memory||Long-term memories can last from minutes to a lifetime, and they are associated with changes in synaptic activity and formation of neuronal circuits in the brain. Dr. Ted Abel is Professor at the University of Iowa and Director of the Iowa Neuroscience Institute. Ted joins me to discuss the transcriptional and epigenetic changes that are also associated with long-term memory.||10/18/2018||Free||View in iTunes|
||CleanEpisode 29: Genome Assembly – A Genomic Jigsaw Puzzle||Sequencing a human genome requires 300 billion bases of DNA sequence, all of which need to be assembled – like a giant genomic jigsaw puzzle. Dr. Aleksey Zimin is Associate Research Scientist at Johns Hopkins University, and he joins me to discuss whole genome sequencing and assembly. He also discusses a novel method for creating phased genome assemblies.||10/3/2018||Free||View in iTunes|
||CleanEpisode 28: Genetics of Deafness and Hearing Loss||Hereditary deafness is a relatively common disorder that affects about 1 in 1000 newborns. Dr. Richard J. Smith is Professor of Otolaryngology at the University of Iowa, and he joins me to discuss the genetic basis of deafness. He also discusses the development of genomic tools to aid in genetic testing of heritable forms of hearing loss.||9/19/2018||Free||View in iTunes|
||CleanEpisode 27: Genetics of Autism and Psychiatric Disorders||Autism is a complex psychiatric disorder that affects 1 in 59 children in the United States. Dr. Jacob Michaelson is Associate Professor of Psychiatry at the University of Iowa and uses genomic and computational techniques to study autism and other psychiatric disorders. He joins me to discuss the genetics of autism and (sparkforautism.org).||9/5/2018||Free||View in iTunes|
||CleanEpisode 26: Genomics and Preimplantation Genetic Screening||In vitro fertilization (IVF) is a reproductive technology used to overcome infertility, an inability to become pregnant that affects 1 in 6 couples. Dr. Nathan Treff is Chief Science Officer of Genomic Prediction in North Brunswick, New Jersey. He discusses the technology behind preimplantation genetic screening (PGS), a genetic test that may improve IVF success rates.||8/23/2018||Free||View in iTunes|
||CleanEpisode 25: Large Scale Genetic Risk Profiling in Dementia||Neurodegenerative diseases are characterized by the death of brain tissues. The causes are unknown, and no effective therapies are available. These diseases can lead to dementia, a medical and economic challenge for society. The UK Dementia Research Institute and Illumina recently hosted a panel of experts to discuss the genetics of dementia, and we feature highlights in this episode.||8/9/2018||Free||View in iTunes|
||CleanEpisode 24: Eczema and the Human Skin Microbiome||Atopic dermatitis (eczema) is a skin inflammation disorder that affects nearly 20% of people. The causes are unknown, but it has been associated with changes in the human skin microbiome. Dr. Julie Segre is Chief of the Translational and Functional Genomics Branch at the NHGRI, in Bethesda, MD. She discusses how NGS is used to study the human skin microbiome and eczema.||7/12/2018||Free||View in iTunes|
||CleanEpisode 23: Using Genetics to Predict Heart Attack Risk||Familial hypercholesterolemia is a genetic disorder leading to elevated cholesterol and early cardiovascular disease. Globally, about 1 in 250 people are affected, but only 10% have been diagnosed. Dr. Guillaume Paré is Professor of Medicine at McMaster University in Hamilton, Ontario, Canada. He discusses how genetics can help identify people at risk of heart attack.||6/27/2018||Free||View in iTunes|
||CleanEpisode 22: Out of Africa - Genetics of the African Diaspora||African populations migrated out of Africa between the 15th and 19th centuries. Understanding the genetics of this African diaspora is providing important insights in human history, health, and disease - especially in populations of African ancestry. Dr. Charles Rotimi of the NHGRI in Bethesda, MD, discusses his research in the genomics of the African diaspora.||6/15/2018||Free||View in iTunes|
||CleanEpisode 21: Cancer Epigenomics - A Cacophony of Gene Expression||Cancer is the second leading cause of death globally. Cancer is driven by DNA sequence errors in genes, or by gene expression changes without DNA sequence errors. This latter process is called epigenetics, and we discuss epigenetics and epigenomics of cancer with Dr. Peter Scacheri, Professor of Genetics and Genome Sciences at Case Western Reserve University in Cleveland, OH.||6/7/2018||Free||View in iTunes|
||CleanEpisode 20: Rare Genes and Rare Diseases||Up to 30 million Americans and 30 million Europeans are currently living with a rare disease. Most are caused by changes in genes but identifying these causative gene sequences can be extremely difficult. Dr. Charis Eng, Chair of Cancer Genomic Medicine at the Cleveland Clinic, discusses the genomics of Cowden's Syndrome, cancer risk, and precision medicine.||5/23/2018||Free||View in iTunes|
||CleanEpisode 19: NHGRI's 2020 Vision for Genomics||The National Human Genome Research Institute, or NHGRI, has launched a new round of strategic planning to establish a 2020 vision for genomics. In a celebration of National DNA Day 2018, Dr. Eric Green, the Director of the NHGRI, joins us for a discussion of the Human Genome Project, the state of genomics today, and where genomics is likely headed in the future.||4/22/2018||Free||View in iTunes|
||CleanEpisode 18: Genetics of Children's Complex Diseases - From GWAS to NGS||Complex diseases are associated with genetic, environmental, and lifestyle factors. Genome-wide association studies, or GWAS, use arrays to identify DNA variants associated with traits or diseases. Professors Struan Grant and Andrew Wells of the Children's Hospital of Philadelphia discuss how they use NGS to map variants to causal genes.||4/11/2018||Free||View in iTunes|
||CleanEpisode 17: Genomics of Endosymbiosis - Cells Within Cells||Eukaryotic cells and their membrane bound organelles evolved from the uptake of a prokaryotic cell into another cell - a process called endosymbiosis. Professors Bebashish Bhattacharya and Dana Price of Rutgers University discuss how single-cell genomics of algae can help unravel the mystery of endosymbiosis and its impact on our health and the environment.||3/29/2018||Free||View in iTunes|
||CleanEpisode 16: Brain on Fire - Genomics of Neuroinflammation||Encephalitis is a brain inflammation that affects 4 million people worldwide. Although caused by infection or by autoimmunity, 50% of cases are never explained. Dr. Michael R. Wilson is Assistant Professor of Neurology at the University of California San Francisco. He discusses how genomics can help us understand the causes of brain inflammation.||3/14/2018||Free||View in iTunes|
||CleanEpisode 15: Human Gut Microbiome - Beneficial Bacteria||The human gut microbiome includes trillions of microbes that are important in health and disease. Genomics has revolutionized our knowledge of human gut microbial complexity. Dr. Ami Bhatt is Professor of Medicine and Genetics at Stanford University. She and her PhD student, Jessica Ribado, discuss how the human gut microbiome impacts human health.||2/22/2018||Free||View in iTunes|
||CleanEpisode 14: Single-Cell Genomics and Cell Ontology||Cell ontology is the vocabulary for defining cell types, and it's important in biology. Single-cell genomics is revolutionizing cell ontology but combining large data sets with classical knowledge is challenging. Dr. Richard Scheuermann, La Jolla Campus Director at the Venter Institute, discusses single-cell sequencing and computational methods to classify cell types.||2/8/2018||Free||View in iTunes|
||CleanEpisode 13: The Human Genome - What Are We Missing?||The human genome was completely sequenced in 2003 - or, was it? Robert Fulton discusses his efforts to try and finally complete the human genome and to build a better human genome reference. Bob is Professor of Genetics at the Washington University School of Medicine, and Director of Development at the McDonnell Genome Institute in Saint Louis, Missouri.||1/25/2018||Free||View in iTunes|
||CleanEpisode 12: Human Microbiome - Our Second Human Genome||We live in harmony with trillions of microbes in and on our bodies - the human microbiome. These microbes outnumber your cells by 10 to 1, and their genes outnumber yours by 100 to 1. But, what do they do? Dr. Kristine and Todd Wylie, Professors of Pediatrics at Washington University in St. Louis, discuss how they use NGS to understand the human microbiome and its association with health.||11/27/2017||Free||View in iTunes|
||CleanEpisode 11: Targeted NGS Empowers Genetic Testing||According to the US National Library of Medicine's Genetic Testing Registry, 10,000 conditions can be identified with genetic testing. The high-throughput and relatively low cost of NGS is advantageous for multigene testing. Dr. Samuel Myllykangas, co-founder of Blueprint Genetics, discusses how current and future NGS innovations may impact genetic testing.||11/3/2017||Free||View in iTunes|
||CleanEpisode 10: Childhood Cancer Risk and Genetics||According to the US National Cancer Institute, 15,000 children and adolescents will be diagnosed with cancer in the United States this year. Fortunately, research has improved the outlook for children with cancer. Dr. Todd Druley, Professor of Medicine at Washington University, discusses how next-generation sequencing is reshaping our understanding of childhood cancer risk and biology.||10/20/2017||Free||View in iTunes|
||CleanEpisode 9: Genomics and Protecting Endangered Species||The critically endangered Saimaa ringed seal is found only in Lake Saimaa, in Finland. Their isolation makes them an excellent model system for studying population and genetic bottlenecks. Dr. Petri Auvinen is a Research Director at the University of Helsinki in Finland. He discusses the Saimaa ringed seal genome project and its impact on saving this animal species from extinction.||10/6/2017||Free||View in iTunes|
||CleanEpisode 8: Making Sense of Cancer Genomes||To enable precision medicine in cancer, health care providers need a solid understanding of genetic information. Drs. Obi and Malachi Griffith are Professors of Medicine at Washington University in St. Louis, MO. They discuss their work in improving bioinformatics education and improving clinical interpretations of sequence variants in cancer.||9/22/2017||Free||View in iTunes|
||CleanEpisode 7: RNA Sequencing in Diagnostics||Personalized medicine involves using a patient's genomic information to better predict disease risk, prognosis, and treatment response. Current genomics-based diagnostic platforms typically use DNA. Dr. Dave Messina is Chief Operations Officer at Cofactor Genomics in St. Louis, MO. He discusses the benefits and the challenges in using RNA sequencing as a diagnostics platform.||9/8/2017||Free||View in iTunes|
||CleanEpisode 6: Genomics and Immune Diseases||In the United States, autoimmune diseases affect 24 million people, resulting in 100 billion dollars of direct health costs annually. Dr. Janna Saarela is Research Director at the Finnish Institute of Molecular Medicine (FIMM) in Helsinki, Finland. She discusses her use of genomics to identify pathogenic mechanisms behind common and rare immune diseases.||8/25/2017||Free||View in iTunes|
||CleanEpisode 5: Food Spoilage and Genomics||Food spoilage in global supply chains costs over 35 billion US dollars annually. Despite these costs, we still don't exactly know what makes food spoil. Dr. Johanna Bjorkroth is Professor of Food Hygiene and Environmental Health at the University of Helsinki. She discusses her use of genomics to identify the microbial causes of food spoilage.||8/10/2017||Free||View in iTunes|
||CleanEpisode 4: Finnish Genetics Aid Disease Research||The country of Finland is the largest population isolate in Europe, with a number of rare alleles enriched in the Finnish population. Dr. Hannele Laivuori and Dr. Mervi Kinnunen coordinate the Sequencing Initiative Suomi and Industry Partnership for Human Genetics projects. They discuss how Finnish genetic information is being used to help disease research.||7/7/2017||Free||View in iTunes|
||CleanEpisode 3: The EMBL Genomics Core Facility||Next generation sequencing, or NGS, has helped to fuel amazing scientific discoveries across a wide range of scientific disciplines. Dr. Vladimir Benes directs the EMBL Genomics Core Facility, and he recently sat down with us to discuss how genomics has impacted and enabled scientific research at EMBL and abroad.||6/6/2017||Free||View in iTunes|
||CleanEpisode 2: Uncovering Enhancer Hijacking Events in Cancer||Genetic variation can impact our susceptibility to developing diseases, like cancer. Dr. Jan Korbel of the EMBL discusses his search for structural variants by using an approach combining computational and laboratory methodology. He discusses his recent work to uncover enhancer hijacking events in cancer.||5/23/2017||Free||View in iTunes|
||CleanEpisode 1: Single-Cell Genomics and Mars||Microbes have been around for billions of years, and they continue to shape our planet and all life on it. Dr. Ramunas Stepanasukas of the Bigelow Laboratory for Ocean Sciences explains how single-cell genomics can help us to better understand microbial diversity and microbial biology. He even discuss how single-cell genomics can help us in our exploration of other planets, like Mars.||3/30/2017||Free||View in iTunes|
Well done and informative!
I am a Sr clinical scientist in a molecular diagnostics oncology laboratory and I LOVE podcasts. This is the best podcast, in my opinion, on the topic of genomics (my favorite followed by true crime and personal finance!) Dr. Bromann at Illumina is doing a great job keeping it interesting, relatable, and bringing on really accomplished guests who share their work and stories.
If you have an interest in healthcare and genomics, I highly recommend!