Inflammation and Neurodegeneration in Multiple Sclerosis
By Projects In Knowledge, Inc
To listen to an audio podcast, mouse over the title and click Play. Open iTunes to download and subscribe to podcasts.
There has been some controversy as to whether inflammation and neurodegeneration in MS may be two independent disease processes and, therefore, whether MS-related neurodegeneration may occur in the absence of inflammation, particularly in patients with progressive disease. A recent study analyzed the interdependence between inflammation, neurodegeneration, and disease progression in the various stages of MS, focusing especially on progressive disease. Join John DeLuca, PhD, as he discusses the results with Claudia Lucchinetti, MD, a member of the study's research team, and explores the implications of this work for the development of new therapies.
||CleanPart 5. Implications for New Therapies||Dr DeLuca and Dr Lucchinetti discuss neuroprotective/neural repair strategies, new targets for novel therapies, and attention to confounding disease.||12/16/2010||Free||View in iTunes|
||CleanPart 4. Unanswered Questions||Dr DeLuca and Dr Lucchinetti discuss the lack of efficacy of anti-inflammatory agents in progressive MS.||12/16/2010||Free||View in iTunes|
||CleanPart 3. Discussion||Dr DeLuca and Dr Lucchinetti discuss the pattern of T- and B-cells and distribution in tissues over time.||12/16/2010||Free||View in iTunes|
||CleanPart 2. Analyzing the Interdependence of Inflammation and Neurodegeneration||Dr DeLuca and Dr Lucchinetti discuss study objective, design and results.||12/16/2010||Free||View in iTunes|
||CleanPart 1. The Inflammation/Neurodegeneration Paradox||Dr DeLuca and Dr Lucchinetti discuss neurodegeneration and inflammation.||12/16/2010||Free||View in iTunes|