When the previous season concluded, House was forced to admit that he had lost his grip on reality and could no longer practice medicine. Out of options, he checked himself into a psychiatric hospital. Beginning with a two-hour premiere set almost entirely inside the psychiatric hospital, Season Six will explore House’s long and twisted road to recovery: Can he find some version of sanity and normalcy? Can he stay away from the workplace that arguably drove him to mental instability but is also the only stable foundation in his life? Can Princeton-Plainsboro continue its celebrated Department of Diagnostics without him? How will Cuddy’s relationship with House change, now that their imagined affair is out in the open?