The second season of Reign begins with Mary and Francis on the throne of a nation burning. France is rocked by the aftereffects of the plague, a disease that creeps inside the castle walls, taking thousands upon thousands of lives across the land, and ravages the stability of a nation. From the ashes, powerful lords will rise, carrying out personal, religious and political vendettas, taking lives, and tearing at Mary and Francis's commitment to each other, and their people. Friendships will be tested, loved ones murdered and betrayed. Meanwhile, a mysterious and deadly threat snatches victims from village streets and castle corridors; leaving evidence of savagery that looks like the work of monsters; mythical creatures who are the subject of nightmares, but who walk among us, doing the Devil's bidding.