Leading up to the fifth season, House has shepherded an elite team of young experts who help him unravel diagnostic mysteries, and he has a good friend and confidant in Dr. James Wilson. There’s some volatile chemistry between House and Dr. Lisa Cuddy. In the Season 4 finale, after a massive bus accident left House without recollection of the accident, he and the team put the pieces of his memory together and discover Wilson’s girlfriend Amber was on the bus with him and was fatally injured. Wilson has to face the shocking realization that House was involved in Amber’s death. As Season Five opens, with his friendship with Wilson shattered, House must determine if he’s responsible for Amber’s death and Wilson must decide if House is a destructive force in his life while Cuddy attempts to advance a reconciliation between the two of them.