Masters of Sex stars Michael Sheen and Lizzy Caplan, who will portray the real-life pioneers of the science of human sexuality, William Masters and Virginia Johnson. The series chronicles the unusual lives, romance and pop culture trajectory of Masters and Johnson. Their research touched off the sexual revolution and took them from a mid-western teaching hospital in St. Louis to the cover of Time magazine. Masters of Sex marks Sheen's first regular series role for television. The series is an adaptation of Thomas Maier's book Masters of Sex: The Life and Times of William Masters and Virginia Johnson, The Couple Who Taught America How To Love. The pilot episode was directed by Academy Award® nominee John Madden (Shakespeare in Love, and the current hit indie film The Best Exotic Marigold Hotel), who also serves as executive producer, and also stars Caitlin Fitzgerald (It's Complicated), in the role of Masters' wife, Nicholas D'Agosto (Heroes) and Teddy Sears (American Horror Story). Emmy and Golden Globe award-winning actor Beau Bridges and Margo Martindale also appear. Masters of Sex was created and executive produced by Michelle Ashford (The Pacific). The series will also be executive produced by Timberman Beverly Productions' Carl Beverly and Sarah Timberman, and Judith Verno. Michael Sheen and Tammy Rosen will serve as producers. Masters of Sex is produced by Sony Pictures Television.