Prey is a high-octane drama about men on the run and the hard-working detective tasked with finding them. In the first story, John Simm stars as Detective Constable Marcus Farrow, a well-liked copper who is found at the scene of a brutal crime with all the evidence pointing towards him. He goes on the run and Detective Sergeant Susan Reinhardt is called into action. In the second story, prison officer Dave Murdock finds himself fleeing authorities when a routine visit to a hospital with a female prisoner spirals out of control. Once again, DS Susan Reinhardt is on the case.