When a person goes missing, every second counts. A&E’s new real life series The First 48: Missing Persons follows the Chicago Police Department’s missing persons unit in the critical first 48 hours of the search for missing loved ones. Based in the heart of one of the country's most colorful law-enforcement cities, the Chicago Police missing persons unit gets more than 17,000 calls each year and is one of the only major police departments in the country that responds to every missing persons call immediately. For the first time ever, the Chicago Police Department gives unrestricted access to ongoing investigations and allows cameras to follow the elite, passionate and dedicated investigators who handle all missing persons and child abduction cases. A spinoff of The First 48, one of the most-watched nonfiction investigative series on cable, each hour-long episode of The First 48: Missing Persons follows the investigation of one or two high-stakes cases, from the moment the call comes in, as detectives search for the husbands, wives, sons and daughters who have disappeared.