Climbers arrive at Everest Base Camp and quickly learn the dangers of the mountain when they hear about a Sherpa's condition. Climbers struggle to push their bodies to acclimate to the extreme altitude four miles above sea level; the climbers are shocked to discover how badly their minds and bodies cope as they move to Advance Base Camp to start their acclimatization climbs.
A cameraman collapses with intense stomach pains and is rushed down the mountain. Back on the North Col, a member of an Indian expedition collapses unconscious with acute mountain sickness. It is up to expedition physician, Terry, to lead a full-scale rescue mission.