They say the third time's the charm, and reformed party girl Kate (Malin Akerman) is hoping that's true when she becomes the third wife of a slightly older man, Pete (Bradley Whitford). They fell into each others' arms (literally) at a karaoke bar, and flash forward a year later, Kate finds herself with an instafamily complete with three stepchildren and two ex-wives. But Kate is determined to make this work and become a part of the family no matter what.
Diane (Marcia Gay Harden) is ex-wife number one, an intense and overachieving former Olympic athlete and the mother of twin teenagers Hillary (Bailee Madison) and Warren (Ryan Scott Lee). Diane is quick to convey her withering disapproval of Kate's barely-tapped maternal instincts. Daughter Hillary is not a fan of her new step-mom either, despite Kate's attempts to win her trust. And son Nelson may have an erotic fixation on his dad's beautiful, young spouse. Ex-wife number two, Jackie (Michaela Watkins), is mother to adopted son Bert (Albert Tsai), and can pull Pete's strings with her special blend of neurotic, New-Ageyness.
Juggling all this baggage is uncharted territory for Kate, who finds support in the most unusual place - with her best friend, Meg (Natalie Morales), a party-hearty singleton and the only woman Kate knows who has less experience with kids than she.