As Season 6 of the Emmy- and Golden Globe-winning drama series begins, Christian and Liz return from their less than blissful honeymoon to begin the process of dissolving their marriage. Heartbroken at how coldly Christian is treating her now that his cancer is in remission and he has a "second chance" at life, Liz decides to get even by taking half of everything he's got. But can she go through with it or will she, too, have a change of heart? Sean and Christian run into Dr. Mike Hamoui (recurring guest star Mario Lopez - Extra), a successful surgeon working in different cities, and make him an interesting offer. Meanwhile, Matt and Kimber seek new and separate careers with little support and much frustration, and Sean remains disillusioned and distant from his lover, Teddy (now played by Rose McGowan - Charmed), despite their seemingly flourishing relationship. Guest stars this season include Gilles Marini, Joan Rivers, and Melanie Griffith.